Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
Identifieur interne : 000904 ( Main/Exploration ); précédent : 000903; suivant : 000905Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
Auteurs : James D. Mckay [France] ; Rayjean J. Hung [Canada] ; Younghun Han [États-Unis] ; Xuchen Zong [Canada] ; Robert Carreras-Torres [France] ; David C. Christiani [États-Unis] ; Neil E. Caporaso [États-Unis] ; Mattias Johansson [France] ; Xiangjun Xiao [États-Unis] ; Yafang Li [États-Unis] ; Jinyoung Byun [États-Unis] ; Alison Dunning [Royaume-Uni] ; Karen A. Pooley [Royaume-Uni] ; David C. Qian [États-Unis] ; Xuemei Ji [États-Unis] ; Geoffrey Liu [Canada] ; Maria N. Timofeeva [France] ; Stig E. Bojesen [Danemark] ; Xifeng Wu [États-Unis] ; Loic Le Marchand [États-Unis] ; Demetrios Albanes [États-Unis] ; Heike Bickeböller [Allemagne] ; Melinda C. Aldrich [États-Unis] ; William S. Bush [États-Unis] ; Adonina Tardon [Espagne] ; Gad Rennert [Israël] ; M Dawn Teare [Royaume-Uni] ; John K. Field [Royaume-Uni] ; Lambertus A. Kiemeney [Pays-Bas] ; Philip Lazarus [États-Unis] ; Aage Haugen [Norvège] ; Stephen Lam [Canada] ; Matthew B. Schabath [États-Unis] ; Angeline S. Andrew [États-Unis] ; Hongbing Shen [République populaire de Chine] ; Yun-Chul Hong [Corée du Sud] ; Jian-Min Yuan [États-Unis] ; Pier Alberto Bertazzi [Italie] ; Angela C. Pesatori [Italie] ; Yuanqing Ye [États-Unis] ; Nancy Diao [États-Unis] ; Li Su [États-Unis] ; Ruyang Zhang [États-Unis] ; Yonathan Brhane [Canada] ; Natasha Leighl [Canada] ; Jakob S. Johansen [Danemark] ; Anders Mellemgaard [Danemark] ; Walid Saliba [Israël] ; Christopher A. Haiman [États-Unis] ; Lynne R. Wilkens [États-Unis] ; Ana Fernandez-Somoano [Espagne] ; Guillermo Fernandez-Tardon [Espagne] ; Henricus F M. Van Der Heijden [Pays-Bas] ; Jin Hee Kim [Corée du Sud] ; Juncheng Dai [République populaire de Chine] ; Zhibin Hu [République populaire de Chine] ; Michael P A. Davies [Royaume-Uni] ; Michael W. Marcus [Royaume-Uni] ; Hans Brunnström [Suède] ; Jonas Manjer [Suède] ; Olle Melander [Suède] ; David C. Muller [Royaume-Uni] ; Kim Overvad [Danemark] ; Antonia Trichopoulou [Grèce] ; Rosario Tumino [Italie] ; Jennifer A. Doherty [États-Unis] ; Matt P. Barnett [États-Unis] ; Chu Chen [États-Unis] ; Gary E. Goodman [États-Unis] ; Angela Cox [Royaume-Uni] ; Fiona Taylor [Royaume-Uni] ; Penella Woll [Royaume-Uni] ; Irene Brüske [Allemagne] ; H-Erich Wichmann [Allemagne] ; Judith Manz [Allemagne] ; Thomas R. Muley [Allemagne] ; Angela Risch [Allemagne] ; Albert Rosenberger [Allemagne] ; Kjell Grankvist [Suède] ; Mikael Johansson [Suède] ; Frances A. Shepherd [Canada] ; Ming-Sound Tsao [Canada] ; Susanne M. Arnold [États-Unis] ; Eric B. Haura [États-Unis] ; Ciprian Bolca [Roumanie] ; Ivana Holcatova [République tchèque] ; Vladimir Janout [République tchèque] ; Milica Kontic [Serbie] ; Jolanta Lissowska [Pologne] ; Anush Mukeria [Russie] ; Simona Ognjanovic [Serbie] ; Tadeusz M. Orlowski [Pologne] ; Ghislaine Scelo [France] ; Beata Swiatkowska [Pologne] ; David Zaridze [Russie] ; Per Bakke [Norvège] ; Vidar Skaug [Norvège] ; Shanbeh Zienolddiny [Norvège] ; Eric J. Duell [Espagne] ; Lesley M. Butler [États-Unis] ; Woon-Puay Koh [Singapour] ; Yu-Tang Gao [République populaire de Chine] ; Richard S. Houlston [Royaume-Uni] ; John Mclaughlin [Canada] ; Victoria L. Stevens [États-Unis] ; Philippe Joubert [Canada] ; Maxime Lamontagne [Canada] ; David C. Nickle [États-Unis] ; Ma'En Obeidat [Canada] ; Wim Timens [Pays-Bas] ; Bin Zhu [États-Unis] ; Lei Song [États-Unis] ; Linda Kachuri [Canada] ; María Soler Artigas [Royaume-Uni] ; Martin D. Tobin [Royaume-Uni] ; Louise V. Wain [Royaume-Uni] ; Thorunn Rafnar [Islande] ; Thorgeir E. Thorgeirsson [Islande] ; Gunnar W. Reginsson [Islande] ; Kari Stefansson [Islande] ; Dana B. Hancock [États-Unis] ; Laura J. Bierut [États-Unis] ; Margaret R. Spitz [États-Unis] ; Nathan C. Gaddis [États-Unis] ; Sharon M. Lutz [États-Unis] ; Fangyi Gu [États-Unis] ; Eric O. Johnson [États-Unis] ; Ahsan Kamal [États-Unis] ; Claudio Pikielny [États-Unis] ; Dakai Zhu [États-Unis] ; Sara Lindströem [États-Unis] ; Xia Jiang [États-Unis] ; Rachel F. Tyndale [Canada] ; Georgia Chenevix-Trench [Australie] ; Jonathan Beesley [Australie] ; Yohan Bossé [Canada] ; Stephen Chanock [États-Unis] ; Paul Brennan [France] ; Maria Teresa Landi [États-Unis] ; Christopher I. Amos [États-Unis]Source :
- Nature genetics [ 1546-1718 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Adénocarcinome (génétique), Cartographie chromosomique, Femelle, Génotype, Homéostasie des télomères (génétique), Humains, Locus de caractère quantitatif, Mâle, Polymorphisme de nucléotide simple, Population d'origine européenne (génétique), Prédisposition génétique à une maladie, Santé de la famille, Sujet âgé, Tabagisme (épidémiologie), Tumeurs du poumon (ethnologie), Tumeurs du poumon (génétique), Tumeurs du poumon (épidémiologie), Étude d'association pangénomique.
- MESH :
- ethnologie : Tumeurs du poumon.
- génétique : Adénocarcinome, Homéostasie des télomères, Population d'origine européenne, Tumeurs du poumon.
- épidémiologie : Tabagisme, Tumeurs du poumon.
- Adulte, Adulte d'âge moyen, Cartographie chromosomique, Femelle, Génotype, Humains, Locus de caractère quantitatif, Mâle, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Santé de la famille, Sujet âgé, Étude d'association pangénomique.
English descriptors
- KwdEn :
- Adenocarcinoma (genetics), Adult, Aged, Chromosome Mapping, European Continental Ancestry Group (genetics), Family Health, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Lung Neoplasms (epidemiology), Lung Neoplasms (ethnology), Lung Neoplasms (genetics), Male, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Smoking (epidemiology), Telomere Homeostasis (genetics).
- MESH :
- epidemiology : Lung Neoplasms, Smoking.
- ethnology : Lung Neoplasms.
- genetics : Adenocarcinoma, European Continental Ancestry Group, Lung Neoplasms, Telomere Homeostasis.
- Adult, Aged, Chromosome Mapping, Family Health, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci.
Abstract
Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
DOI: 10.1038/ng.3892
PubMed: 28604730
Affiliations:
- Allemagne, Australie, Canada, Corée du Sud, Danemark, Espagne, France, Grèce, Islande, Israël, Italie, Norvège, Pays-Bas, Pologne, Roumanie, Royaume-Uni, Russie, République populaire de Chine, République tchèque, Serbie, Singapour, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Attique (région), Auvergne-Rhône-Alpes, Bade-Wurtemberg, Basse-Saxe, Bohême centrale, Californie, Caroline du Nord, Catalogne, Colorado, District de Karlsruhe, District fédéral central, Floride, Grand Londres, Groningue (province), Gueldre, Géorgie (États-Unis), Hawaï, Hovedstaden, Kentucky, Lombardie, Maryland, Massachusetts, Missouri (État), New Hampshire, Ohio, Ontario, Pennsylvanie, Rhône-Alpes, Région capitale de Séoul, Tennessee, Texas, Washington (État), Østlandet
- Athènes, Barcelone, Cambridge, Copenhague, Groningue, Groningue (ville), Göttingen, Heidelberg, Londres, Lyon, Milan, Moscou, Nimègue, Oslo, Prague, Saint-Louis (Missouri), Seattle, Séoul, Toronto
- Université de Cambridge, Université de Groningue, Université de Toronto, Université de Washington, École de médecine (Université Washington de Saint-Louis)
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Le document en format XML
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Timofeeva</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, World Health Organization, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, World Health Organization, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Albanes, Demetrios" sort="Albanes, Demetrios" uniqKey="Albanes D" first="Demetrios" last="Albanes">Demetrios Albanes</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Aldrich, Melinda C" sort="Aldrich, Melinda C" uniqKey="Aldrich M" first="Melinda C" last="Aldrich">Melinda C. Aldrich</name><affiliation wicri:level="2"><nlm:affiliation>Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Bush, William S" sort="Bush, William S" uniqKey="Bush W" first="William S" last="Bush">William S. Bush</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Tardon, Adonina" sort="Tardon, Adonina" uniqKey="Tardon A" first="Adonina" last="Tardon">Adonina Tardon</name><affiliation wicri:level="1"><nlm:affiliation>University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation wicri:level="1"><nlm:affiliation>Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Teare, M Dawn" sort="Teare, M Dawn" uniqKey="Teare M" first="M Dawn" last="Teare">M Dawn Teare</name><affiliation wicri:level="1"><nlm:affiliation>School of Health and Related Research, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Health and Related Research, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Field, John K" sort="Field, John K" uniqKey="Field J" first="John K" last="Field">John K. Field</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Translational Medicine, University of Liverpool, Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Translational Medicine, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A" last="Kiemeney">Lambertus A. Kiemeney</name><affiliation wicri:level="3"><nlm:affiliation>Departments of Health Evidence and Urology, Radboud University Medical Center, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Health Evidence and Urology, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Lazarus, Philip" sort="Lazarus, Philip" uniqKey="Lazarus P" first="Philip" last="Lazarus">Philip Lazarus</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Haugen, Aage" sort="Haugen, Aage" uniqKey="Haugen A" first="Aage" last="Haugen">Aage Haugen</name><affiliation wicri:level="3"><nlm:affiliation>National Institute of Occupational Health, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>National Institute of Occupational Health, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Lam, Stephen" sort="Lam, Stephen" uniqKey="Lam S" first="Stephen" last="Lam">Stephen Lam</name><affiliation wicri:level="1"><nlm:affiliation>British Columbia Cancer Agency, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>British Columbia Cancer Agency, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Schabath, Matthew B" sort="Schabath, Matthew B" uniqKey="Schabath M" first="Matthew B" last="Schabath">Matthew B. Schabath</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Andrew, Angeline S" sort="Andrew, Angeline S" uniqKey="Andrew A" first="Angeline S" last="Andrew">Angeline S. Andrew</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Geisel School of Medicine, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Geisel School of Medicine, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Hong, Yun Chul" sort="Hong, Yun Chul" uniqKey="Hong Y" first="Yun-Chul" last="Hong">Yun-Chul Hong</name><affiliation wicri:level="3"><nlm:affiliation>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Bertazzi, Pier Alberto" sort="Bertazzi, Pier Alberto" uniqKey="Bertazzi P" first="Pier Alberto" last="Bertazzi">Pier Alberto Bertazzi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Preventive Medicine, IRCCS Foundation Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Preventive Medicine, IRCCS Foundation Cà Granda Ospedale Maggiore Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pesatori, Angela C" sort="Pesatori, Angela C" uniqKey="Pesatori A" first="Angela C" last="Pesatori">Angela C. Pesatori</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Sciences and Community Health-DISCCO, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Sciences and Community Health-DISCCO, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Ye, Yuanqing" sort="Ye, Yuanqing" uniqKey="Ye Y" first="Yuanqing" last="Ye">Yuanqing Ye</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Diao, Nancy" sort="Diao, Nancy" uniqKey="Diao N" first="Nancy" last="Diao">Nancy Diao</name><affiliation wicri:level="2"><nlm:affiliation>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Su, Li" sort="Su, Li" uniqKey="Su L" first="Li" last="Su">Li Su</name><affiliation wicri:level="2"><nlm:affiliation>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Zhang, Ruyang" sort="Zhang, Ruyang" uniqKey="Zhang R" first="Ruyang" last="Zhang">Ruyang Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Brhane, Yonathan" sort="Brhane, Yonathan" uniqKey="Brhane Y" first="Yonathan" last="Brhane">Yonathan Brhane</name><affiliation wicri:level="4"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Leighl, Natasha" sort="Leighl, Natasha" uniqKey="Leighl N" first="Natasha" last="Leighl">Natasha Leighl</name><affiliation wicri:level="1"><nlm:affiliation>University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Johansen, Jakob S" sort="Johansen, Jakob S" uniqKey="Johansen J" first="Jakob S" last="Johansen">Jakob S. Johansen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Mellemgaard, Anders" sort="Mellemgaard, Anders" uniqKey="Mellemgaard A" first="Anders" last="Mellemgaard">Anders Mellemgaard</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Saliba, Walid" sort="Saliba, Walid" uniqKey="Saliba W" first="Walid" last="Saliba">Walid Saliba</name><affiliation wicri:level="1"><nlm:affiliation>Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wilkens, Lynne R" sort="Wilkens, Lynne R" uniqKey="Wilkens L" first="Lynne R" last="Wilkens">Lynne R. Wilkens</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Fernandez Somoano, Ana" sort="Fernandez Somoano, Ana" uniqKey="Fernandez Somoano A" first="Ana" last="Fernandez-Somoano">Ana Fernandez-Somoano</name><affiliation wicri:level="1"><nlm:affiliation>University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Tardon, Guillermo" sort="Fernandez Tardon, Guillermo" uniqKey="Fernandez Tardon G" first="Guillermo" last="Fernandez-Tardon">Guillermo Fernandez-Tardon</name><affiliation wicri:level="1"><nlm:affiliation>University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Heijden, Henricus F M" sort="Van Der Heijden, Henricus F M" uniqKey="Van Der Heijden H" first="Henricus F M" last="Van Der Heijden">Henricus F M. Van Der Heijden</name><affiliation wicri:level="3"><nlm:affiliation>Departments of Health Evidence and Urology, Radboud University Medical Center, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Health Evidence and Urology, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Kim, Jin Hee" sort="Kim, Jin Hee" uniqKey="Kim J" first="Jin Hee" last="Kim">Jin Hee Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Dai, Juncheng" sort="Dai, Juncheng" uniqKey="Dai J" first="Juncheng" last="Dai">Juncheng Dai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Davies, Michael P A" sort="Davies, Michael P A" uniqKey="Davies M" first="Michael P A" last="Davies">Michael P A. Davies</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Translational Medicine, University of Liverpool, Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Translational Medicine, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Marcus, Michael W" sort="Marcus, Michael W" uniqKey="Marcus M" first="Michael W" last="Marcus">Michael W. Marcus</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Translational Medicine, University of Liverpool, Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Translational Medicine, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Brunnstrom, Hans" sort="Brunnstrom, Hans" uniqKey="Brunnstrom H" first="Hans" last="Brunnström">Hans Brunnström</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pathology, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Manjer, Jonas" sort="Manjer, Jonas" uniqKey="Manjer J" first="Jonas" last="Manjer">Jonas Manjer</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Faculty of Medicine, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Faculty of Medicine, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Muller, David C" sort="Muller, David C" uniqKey="Muller D" first="David C" last="Muller">David C. Muller</name><affiliation wicri:level="3"><nlm:affiliation>School of Public Health, St Mary's Campus, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Public Health, St Mary's Campus, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation wicri:level="1"><nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation wicri:level="3"><nlm:affiliation>Hellenic Health Foundation, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name><affiliation wicri:level="1"><nlm:affiliation>Molecular and Nutritional Epidemiology Unit, CSPO (Cancer Research and Prevention Centre), Scientific Institute of Tuscany, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular and Nutritional Epidemiology Unit, CSPO (Cancer Research and Prevention Centre), Scientific Institute of Tuscany, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Doherty, Jennifer A" sort="Doherty, Jennifer A" uniqKey="Doherty J" first="Jennifer A" last="Doherty">Jennifer A. Doherty</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Geisel School of Medicine, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Geisel School of Medicine, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Barnett, Matt P" sort="Barnett, Matt P" uniqKey="Barnett M" first="Matt P" last="Barnett">Matt P. Barnett</name><affiliation wicri:level="2"><nlm:affiliation>Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name><affiliation wicri:level="2"><nlm:affiliation>Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E" last="Goodman">Gary E. Goodman</name><affiliation wicri:level="2"><nlm:affiliation>Swedish Medical Group, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Swedish Medical Group, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Fiona" sort="Taylor, Fiona" uniqKey="Taylor F" first="Fiona" last="Taylor">Fiona Taylor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Woll, Penella" sort="Woll, Penella" uniqKey="Woll P" first="Penella" last="Woll">Penella Woll</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Bruske, Irene" sort="Bruske, Irene" uniqKey="Bruske I" first="Irene" last="Brüske">Irene Brüske</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Manz, Judith" sort="Manz, Judith" uniqKey="Manz J" first="Judith" last="Manz">Judith Manz</name><affiliation wicri:level="1"><nlm:affiliation>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Muley, Thomas R" sort="Muley, Thomas R" uniqKey="Muley T" first="Thomas R" last="Muley">Thomas R. Muley</name><affiliation wicri:level="3"><nlm:affiliation>Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thoraxklinik at University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation wicri:level="1"><nlm:affiliation>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Rosenberger, Albert" sort="Rosenberger, Albert" uniqKey="Rosenberger A" first="Albert" last="Rosenberger">Albert Rosenberger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Grankvist, Kjell" sort="Grankvist, Kjell" uniqKey="Grankvist K" first="Kjell" last="Grankvist">Kjell Grankvist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biosciences, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Biosciences, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Johansson, Mikael" sort="Johansson, Mikael" uniqKey="Johansson M" first="Mikael" last="Johansson">Mikael Johansson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Sciences, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Radiation Sciences, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Shepherd, Frances A" sort="Shepherd, Frances A" uniqKey="Shepherd F" first="Frances A" last="Shepherd">Frances A. Shepherd</name><affiliation wicri:level="1"><nlm:affiliation>University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Tsao, Ming Sound" sort="Tsao, Ming Sound" uniqKey="Tsao M" first="Ming-Sound" last="Tsao">Ming-Sound Tsao</name><affiliation wicri:level="1"><nlm:affiliation>University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Arnold, Susanne M" sort="Arnold, Susanne M" uniqKey="Arnold S" first="Susanne M" last="Arnold">Susanne M. Arnold</name><affiliation wicri:level="2"><nlm:affiliation>Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Markey Cancer Center, University of Kentucky, Lexington, Kentucky</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Haura, Eric B" sort="Haura, Eric B" uniqKey="Haura E" first="Eric B" last="Haura">Eric B. Haura</name><affiliation wicri:level="2"><nlm:affiliation>Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Bolca, Ciprian" sort="Bolca, Ciprian" uniqKey="Bolca C" first="Ciprian" last="Bolca">Ciprian Bolca</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pneumology 'Marius Nasta', Bucharest, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Institute of Pneumology 'Marius Nasta', Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Holcatova, Ivana" sort="Holcatova, Ivana" uniqKey="Holcatova I" first="Ivana" last="Holcatova">Ivana Holcatova</name><affiliation wicri:level="3"><nlm:affiliation>2nd Faculty of Medicine, Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>2nd Faculty of Medicine, Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Janout, Vladimir" sort="Janout, Vladimir" uniqKey="Janout V" first="Vladimir" last="Janout">Vladimir Janout</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Faculty of Medicine, University of Ostrava, Ostrava</wicri:regionArea><wicri:noRegion>Ostrava</wicri:noRegion></affiliation></author><author><name sortKey="Kontic, Milica" sort="Kontic, Milica" uniqKey="Kontic M" first="Milica" last="Kontic">Milica Kontic</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Center of Serbia, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation wicri:level="1"><nlm:affiliation>M. Sklodowska-Curie Cancer Center, Institute of Oncology, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>M. Sklodowska-Curie Cancer Center, Institute of Oncology, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Mukeria, Anush" sort="Mukeria, Anush" uniqKey="Mukeria A" first="Anush" last="Mukeria">Anush Mukeria</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre, Moscow, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Ognjanovic, Simona" sort="Ognjanovic, Simona" uniqKey="Ognjanovic S" first="Simona" last="Ognjanovic">Simona Ognjanovic</name><affiliation wicri:level="1"><nlm:affiliation>International Organization for Cancer Prevention and Research, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>International Organization for Cancer Prevention and Research, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Orlowski, Tadeusz M" sort="Orlowski, Tadeusz M" uniqKey="Orlowski T" first="Tadeusz M" last="Orlowski">Tadeusz M. Orlowski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Surgery, National Tuberculosis and Lung Diseases Research Institute, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Scelo, Ghislaine" sort="Scelo, Ghislaine" uniqKey="Scelo G" first="Ghislaine" last="Scelo">Ghislaine Scelo</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, World Health Organization, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, World Health Organization, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Swiatkowska, Beata" sort="Swiatkowska, Beata" uniqKey="Swiatkowska B" first="Beata" last="Swiatkowska">Beata Swiatkowska</name><affiliation wicri:level="1"><nlm:affiliation>Nofer Institute of Occupational Medicine, Department of Environmental Epidemiology, Lodz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Nofer Institute of Occupational Medicine, Department of Environmental Epidemiology, Lodz</wicri:regionArea><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Zaridze, David" sort="Zaridze, David" uniqKey="Zaridze D" first="David" last="Zaridze">David Zaridze</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre, Moscow, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Bakke, Per" sort="Bakke, Per" uniqKey="Bakke P" first="Per" last="Bakke">Per Bakke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Science, University of Bergen, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Science, University of Bergen, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Skaug, Vidar" sort="Skaug, Vidar" uniqKey="Skaug V" first="Vidar" last="Skaug">Vidar Skaug</name><affiliation wicri:level="3"><nlm:affiliation>National Institute of Occupational Health, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>National Institute of Occupational Health, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Zienolddiny, Shanbeh" sort="Zienolddiny, Shanbeh" uniqKey="Zienolddiny S" first="Shanbeh" last="Zienolddiny">Shanbeh Zienolddiny</name><affiliation wicri:level="3"><nlm:affiliation>National Institute of Occupational Health, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>National Institute of Occupational Health, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Butler, Lesley M" sort="Butler, Lesley M" uniqKey="Butler L" first="Lesley M" last="Butler">Lesley M. Butler</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Koh, Woon Puay" sort="Koh, Woon Puay" uniqKey="Koh W" first="Woon-Puay" last="Koh">Woon-Puay Koh</name><affiliation wicri:level="1"><nlm:affiliation>Duke-National University of Singapore Medical School, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-National University of Singapore Medical School</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S" last="Houlston">Richard S. Houlston</name><affiliation wicri:level="3"><nlm:affiliation>The Institute of Cancer Research, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mclaughlin, John" sort="Mclaughlin, John" uniqKey="Mclaughlin J" first="John" last="Mclaughlin">John Mclaughlin</name><affiliation wicri:level="1"><nlm:affiliation>Public Health Ontario, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Public Health Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L" last="Stevens">Victoria L. Stevens</name><affiliation wicri:level="2"><nlm:affiliation>American Cancer Society, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>American Cancer Society, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Joubert, Philippe" sort="Joubert, Philippe" uniqKey="Joubert P" first="Philippe" last="Joubert">Philippe Joubert</name><affiliation wicri:level="1"><nlm:affiliation>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Lamontagne, Maxime" sort="Lamontagne, Maxime" uniqKey="Lamontagne M" first="Maxime" last="Lamontagne">Maxime Lamontagne</name><affiliation wicri:level="1"><nlm:affiliation>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Nickle, David C" sort="Nickle, David C" uniqKey="Nickle D" first="David C" last="Nickle">David C. Nickle</name><affiliation wicri:level="2"><nlm:affiliation>Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Obeidat, Ma En" sort="Obeidat, Ma En" uniqKey="Obeidat M" first="Ma'En" last="Obeidat">Ma'En Obeidat</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name><affiliation wicri:level="4"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, GRIAC Research Institute, Groningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, GRIAC Research Institute, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Zhu, Bin" sort="Zhu, Bin" uniqKey="Zhu B" first="Bin" last="Zhu">Bin Zhu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Song, Lei" sort="Song, Lei" uniqKey="Song L" first="Lei" last="Song">Lei Song</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kachuri, Linda" sort="Kachuri, Linda" uniqKey="Kachuri L" first="Linda" last="Kachuri">Linda Kachuri</name><affiliation wicri:level="4"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Artigas, Maria Soler" sort="Artigas, Maria Soler" uniqKey="Artigas M" first="María Soler" last="Artigas">María Soler Artigas</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D" last="Tobin">Martin D. Tobin</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Wain, Louise V" sort="Wain, Louise V" uniqKey="Wain L" first="Louise V" last="Wain">Louise V. Wain</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics, Amgen, Inc., Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Amgen, Inc., Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorgeirsson, Thorgeir E" sort="Thorgeirsson, Thorgeir E" uniqKey="Thorgeirsson T" first="Thorgeir E" last="Thorgeirsson">Thorgeir E. Thorgeirsson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics, Amgen, Inc., Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Amgen, Inc., Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Reginsson, Gunnar W" sort="Reginsson, Gunnar W" uniqKey="Reginsson G" first="Gunnar W" last="Reginsson">Gunnar W. Reginsson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics, Amgen, Inc., Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Amgen, Inc., Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics, Amgen, Inc., Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Amgen, Inc., Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Hancock, Dana B" sort="Hancock, Dana B" uniqKey="Hancock D" first="Dana B" last="Hancock">Dana B. Hancock</name><affiliation wicri:level="2"><nlm:affiliation>Behavioral and Urban Health Program, Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, North Carolina, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Behavioral and Urban Health Program, Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Bierut, Laura J" sort="Bierut, Laura J" uniqKey="Bierut L" first="Laura J" last="Bierut">Laura J. Bierut</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Spitz, Margaret R" sort="Spitz, Margaret R" uniqKey="Spitz M" first="Margaret R" last="Spitz">Margaret R. Spitz</name><affiliation wicri:level="2"><nlm:affiliation>Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duncan Cancer Center, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Gaddis, Nathan C" sort="Gaddis, Nathan C" uniqKey="Gaddis N" first="Nathan C" last="Gaddis">Nathan C. Gaddis</name><affiliation wicri:level="2"><nlm:affiliation>Research Computing Division, RTI International, Research Triangle Park, North Carolina, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Research Computing Division, RTI International, Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Lutz, Sharon M" sort="Lutz, Sharon M" uniqKey="Lutz S" first="Sharon M" last="Lutz">Sharon M. Lutz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Gu, Fangyi" sort="Gu, Fangyi" uniqKey="Gu F" first="Fangyi" last="Gu">Fangyi Gu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Johnson, Eric O" sort="Johnson, Eric O" uniqKey="Johnson E" first="Eric O" last="Johnson">Eric O. Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Fellow Program and Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, North Carolina, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fellow Program and Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Kamal, Ahsan" sort="Kamal, Ahsan" uniqKey="Kamal A" first="Ahsan" last="Kamal">Ahsan Kamal</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Pikielny, Claudio" sort="Pikielny, Claudio" uniqKey="Pikielny C" first="Claudio" last="Pikielny">Claudio Pikielny</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Zhu, Dakai" sort="Zhu, Dakai" uniqKey="Zhu D" first="Dakai" last="Zhu">Dakai Zhu</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Lindstroem, Sara" sort="Lindstroem, Sara" uniqKey="Lindstroem S" first="Sara" last="Lindströem">Sara Lindströem</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Jiang, Xia" sort="Jiang, Xia" uniqKey="Jiang X" first="Xia" last="Jiang">Xia Jiang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Tyndale, Rachel F" sort="Tyndale, Rachel F" uniqKey="Tyndale R" first="Rachel F" last="Tyndale">Rachel F. Tyndale</name><affiliation wicri:level="4"><nlm:affiliation>Departments of Pharmacology and Toxicology &Psychiatry, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Pharmacology and Toxicology &Psychiatry, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><affiliation wicri:level="1"><nlm:affiliation>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Chanock, Stephen" sort="Chanock, Stephen" uniqKey="Chanock S" first="Stephen" last="Chanock">Stephen Chanock</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, World Health Organization, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, World Health Organization, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I" last="Amos">Christopher I. Amos</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28604730</idno><idno type="pmid">28604730</idno><idno type="doi">10.1038/ng.3892</idno><idno type="wicri:Area/PubMed/Corpus">000894</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000894</idno><idno type="wicri:Area/PubMed/Curation">000891</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000891</idno><idno type="wicri:Area/PubMed/Checkpoint">000891</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000891</idno><idno type="wicri:Area/Ncbi/Merge">004965</idno><idno type="wicri:Area/Ncbi/Curation">004965</idno><idno type="wicri:Area/Ncbi/Checkpoint">004965</idno><idno type="wicri:Area/Main/Merge">000899</idno><idno type="wicri:Area/Main/Curation">000904</idno><idno type="wicri:Area/Main/Exploration">000904</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.</title><author><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D" last="Mckay">James D. Mckay</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, World Health Organization, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, World Health Organization, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J" last="Hung">Rayjean J. Hung</name><affiliation wicri:level="4"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Han, Younghun" sort="Han, Younghun" uniqKey="Han Y" first="Younghun" last="Han">Younghun Han</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Zong, Xuchen" sort="Zong, Xuchen" uniqKey="Zong X" first="Xuchen" last="Zong">Xuchen Zong</name><affiliation wicri:level="4"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Carreras Torres, Robert" sort="Carreras Torres, Robert" uniqKey="Carreras Torres R" first="Robert" last="Carreras-Torres">Robert Carreras-Torres</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, World Health Organization, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, World Health Organization, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C" last="Christiani">David C. Christiani</name><affiliation wicri:level="2"><nlm:affiliation>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, World Health Organization, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, World Health Organization, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Xiao, Xiangjun" sort="Xiao, Xiangjun" uniqKey="Xiao X" first="Xiangjun" last="Xiao">Xiangjun Xiao</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Li, Yafang" sort="Li, Yafang" uniqKey="Li Y" first="Yafang" last="Li">Yafang Li</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Byun, Jinyoung" sort="Byun, Jinyoung" uniqKey="Byun J" first="Jinyoung" last="Byun">Jinyoung Byun</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Dunning, Alison" sort="Dunning, Alison" uniqKey="Dunning A" first="Alison" last="Dunning">Alison Dunning</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A" last="Pooley">Karen A. Pooley</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Qian, David C" sort="Qian, David C" uniqKey="Qian D" first="David C" last="Qian">David C. Qian</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Ji, Xuemei" sort="Ji, Xuemei" uniqKey="Ji X" first="Xuemei" last="Ji">Xuemei Ji</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Liu, Geoffrey" sort="Liu, Geoffrey" uniqKey="Liu G" first="Geoffrey" last="Liu">Geoffrey Liu</name><affiliation wicri:level="4"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Timofeeva, Maria N" sort="Timofeeva, Maria N" uniqKey="Timofeeva M" first="Maria N" last="Timofeeva">Maria N. Timofeeva</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, World Health Organization, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, World Health Organization, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Albanes, Demetrios" sort="Albanes, Demetrios" uniqKey="Albanes D" first="Demetrios" last="Albanes">Demetrios Albanes</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Aldrich, Melinda C" sort="Aldrich, Melinda C" uniqKey="Aldrich M" first="Melinda C" last="Aldrich">Melinda C. Aldrich</name><affiliation wicri:level="2"><nlm:affiliation>Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Bush, William S" sort="Bush, William S" uniqKey="Bush W" first="William S" last="Bush">William S. Bush</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Tardon, Adonina" sort="Tardon, Adonina" uniqKey="Tardon A" first="Adonina" last="Tardon">Adonina Tardon</name><affiliation wicri:level="1"><nlm:affiliation>University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation wicri:level="1"><nlm:affiliation>Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Teare, M Dawn" sort="Teare, M Dawn" uniqKey="Teare M" first="M Dawn" last="Teare">M Dawn Teare</name><affiliation wicri:level="1"><nlm:affiliation>School of Health and Related Research, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Health and Related Research, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Field, John K" sort="Field, John K" uniqKey="Field J" first="John K" last="Field">John K. Field</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Translational Medicine, University of Liverpool, Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Translational Medicine, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A" last="Kiemeney">Lambertus A. Kiemeney</name><affiliation wicri:level="3"><nlm:affiliation>Departments of Health Evidence and Urology, Radboud University Medical Center, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Health Evidence and Urology, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Lazarus, Philip" sort="Lazarus, Philip" uniqKey="Lazarus P" first="Philip" last="Lazarus">Philip Lazarus</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Haugen, Aage" sort="Haugen, Aage" uniqKey="Haugen A" first="Aage" last="Haugen">Aage Haugen</name><affiliation wicri:level="3"><nlm:affiliation>National Institute of Occupational Health, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>National Institute of Occupational Health, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Lam, Stephen" sort="Lam, Stephen" uniqKey="Lam S" first="Stephen" last="Lam">Stephen Lam</name><affiliation wicri:level="1"><nlm:affiliation>British Columbia Cancer Agency, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>British Columbia Cancer Agency, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Schabath, Matthew B" sort="Schabath, Matthew B" uniqKey="Schabath M" first="Matthew B" last="Schabath">Matthew B. Schabath</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Andrew, Angeline S" sort="Andrew, Angeline S" uniqKey="Andrew A" first="Angeline S" last="Andrew">Angeline S. Andrew</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Geisel School of Medicine, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Geisel School of Medicine, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Hong, Yun Chul" sort="Hong, Yun Chul" uniqKey="Hong Y" first="Yun-Chul" last="Hong">Yun-Chul Hong</name><affiliation wicri:level="3"><nlm:affiliation>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Bertazzi, Pier Alberto" sort="Bertazzi, Pier Alberto" uniqKey="Bertazzi P" first="Pier Alberto" last="Bertazzi">Pier Alberto Bertazzi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Preventive Medicine, IRCCS Foundation Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Preventive Medicine, IRCCS Foundation Cà Granda Ospedale Maggiore Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pesatori, Angela C" sort="Pesatori, Angela C" uniqKey="Pesatori A" first="Angela C" last="Pesatori">Angela C. Pesatori</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Sciences and Community Health-DISCCO, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Sciences and Community Health-DISCCO, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Ye, Yuanqing" sort="Ye, Yuanqing" uniqKey="Ye Y" first="Yuanqing" last="Ye">Yuanqing Ye</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Diao, Nancy" sort="Diao, Nancy" uniqKey="Diao N" first="Nancy" last="Diao">Nancy Diao</name><affiliation wicri:level="2"><nlm:affiliation>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Su, Li" sort="Su, Li" uniqKey="Su L" first="Li" last="Su">Li Su</name><affiliation wicri:level="2"><nlm:affiliation>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Zhang, Ruyang" sort="Zhang, Ruyang" uniqKey="Zhang R" first="Ruyang" last="Zhang">Ruyang Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Brhane, Yonathan" sort="Brhane, Yonathan" uniqKey="Brhane Y" first="Yonathan" last="Brhane">Yonathan Brhane</name><affiliation wicri:level="4"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Leighl, Natasha" sort="Leighl, Natasha" uniqKey="Leighl N" first="Natasha" last="Leighl">Natasha Leighl</name><affiliation wicri:level="1"><nlm:affiliation>University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Johansen, Jakob S" sort="Johansen, Jakob S" uniqKey="Johansen J" first="Jakob S" last="Johansen">Jakob S. Johansen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Mellemgaard, Anders" sort="Mellemgaard, Anders" uniqKey="Mellemgaard A" first="Anders" last="Mellemgaard">Anders Mellemgaard</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Saliba, Walid" sort="Saliba, Walid" uniqKey="Saliba W" first="Walid" last="Saliba">Walid Saliba</name><affiliation wicri:level="1"><nlm:affiliation>Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wilkens, Lynne R" sort="Wilkens, Lynne R" uniqKey="Wilkens L" first="Lynne R" last="Wilkens">Lynne R. Wilkens</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Fernandez Somoano, Ana" sort="Fernandez Somoano, Ana" uniqKey="Fernandez Somoano A" first="Ana" last="Fernandez-Somoano">Ana Fernandez-Somoano</name><affiliation wicri:level="1"><nlm:affiliation>University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Tardon, Guillermo" sort="Fernandez Tardon, Guillermo" uniqKey="Fernandez Tardon G" first="Guillermo" last="Fernandez-Tardon">Guillermo Fernandez-Tardon</name><affiliation wicri:level="1"><nlm:affiliation>University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Heijden, Henricus F M" sort="Van Der Heijden, Henricus F M" uniqKey="Van Der Heijden H" first="Henricus F M" last="Van Der Heijden">Henricus F M. Van Der Heijden</name><affiliation wicri:level="3"><nlm:affiliation>Departments of Health Evidence and Urology, Radboud University Medical Center, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Health Evidence and Urology, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Kim, Jin Hee" sort="Kim, Jin Hee" uniqKey="Kim J" first="Jin Hee" last="Kim">Jin Hee Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Dai, Juncheng" sort="Dai, Juncheng" uniqKey="Dai J" first="Juncheng" last="Dai">Juncheng Dai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Davies, Michael P A" sort="Davies, Michael P A" uniqKey="Davies M" first="Michael P A" last="Davies">Michael P A. Davies</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Translational Medicine, University of Liverpool, Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Translational Medicine, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Marcus, Michael W" sort="Marcus, Michael W" uniqKey="Marcus M" first="Michael W" last="Marcus">Michael W. Marcus</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Translational Medicine, University of Liverpool, Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Translational Medicine, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Brunnstrom, Hans" sort="Brunnstrom, Hans" uniqKey="Brunnstrom H" first="Hans" last="Brunnström">Hans Brunnström</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pathology, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Manjer, Jonas" sort="Manjer, Jonas" uniqKey="Manjer J" first="Jonas" last="Manjer">Jonas Manjer</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Faculty of Medicine, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Faculty of Medicine, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Muller, David C" sort="Muller, David C" uniqKey="Muller D" first="David C" last="Muller">David C. Muller</name><affiliation wicri:level="3"><nlm:affiliation>School of Public Health, St Mary's Campus, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Public Health, St Mary's Campus, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation wicri:level="1"><nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation wicri:level="3"><nlm:affiliation>Hellenic Health Foundation, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name><affiliation wicri:level="1"><nlm:affiliation>Molecular and Nutritional Epidemiology Unit, CSPO (Cancer Research and Prevention Centre), Scientific Institute of Tuscany, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular and Nutritional Epidemiology Unit, CSPO (Cancer Research and Prevention Centre), Scientific Institute of Tuscany, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Doherty, Jennifer A" sort="Doherty, Jennifer A" uniqKey="Doherty J" first="Jennifer A" last="Doherty">Jennifer A. Doherty</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Geisel School of Medicine, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Geisel School of Medicine, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Barnett, Matt P" sort="Barnett, Matt P" uniqKey="Barnett M" first="Matt P" last="Barnett">Matt P. Barnett</name><affiliation wicri:level="2"><nlm:affiliation>Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name><affiliation wicri:level="2"><nlm:affiliation>Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E" last="Goodman">Gary E. Goodman</name><affiliation wicri:level="2"><nlm:affiliation>Swedish Medical Group, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Swedish Medical Group, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Fiona" sort="Taylor, Fiona" uniqKey="Taylor F" first="Fiona" last="Taylor">Fiona Taylor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Woll, Penella" sort="Woll, Penella" uniqKey="Woll P" first="Penella" last="Woll">Penella Woll</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Bruske, Irene" sort="Bruske, Irene" uniqKey="Bruske I" first="Irene" last="Brüske">Irene Brüske</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Manz, Judith" sort="Manz, Judith" uniqKey="Manz J" first="Judith" last="Manz">Judith Manz</name><affiliation wicri:level="1"><nlm:affiliation>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Muley, Thomas R" sort="Muley, Thomas R" uniqKey="Muley T" first="Thomas R" last="Muley">Thomas R. Muley</name><affiliation wicri:level="3"><nlm:affiliation>Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thoraxklinik at University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation wicri:level="1"><nlm:affiliation>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Rosenberger, Albert" sort="Rosenberger, Albert" uniqKey="Rosenberger A" first="Albert" last="Rosenberger">Albert Rosenberger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Grankvist, Kjell" sort="Grankvist, Kjell" uniqKey="Grankvist K" first="Kjell" last="Grankvist">Kjell Grankvist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biosciences, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Biosciences, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Johansson, Mikael" sort="Johansson, Mikael" uniqKey="Johansson M" first="Mikael" last="Johansson">Mikael Johansson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Sciences, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Radiation Sciences, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Shepherd, Frances A" sort="Shepherd, Frances A" uniqKey="Shepherd F" first="Frances A" last="Shepherd">Frances A. Shepherd</name><affiliation wicri:level="1"><nlm:affiliation>University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Tsao, Ming Sound" sort="Tsao, Ming Sound" uniqKey="Tsao M" first="Ming-Sound" last="Tsao">Ming-Sound Tsao</name><affiliation wicri:level="1"><nlm:affiliation>University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Arnold, Susanne M" sort="Arnold, Susanne M" uniqKey="Arnold S" first="Susanne M" last="Arnold">Susanne M. Arnold</name><affiliation wicri:level="2"><nlm:affiliation>Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Markey Cancer Center, University of Kentucky, Lexington, Kentucky</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Haura, Eric B" sort="Haura, Eric B" uniqKey="Haura E" first="Eric B" last="Haura">Eric B. Haura</name><affiliation wicri:level="2"><nlm:affiliation>Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Bolca, Ciprian" sort="Bolca, Ciprian" uniqKey="Bolca C" first="Ciprian" last="Bolca">Ciprian Bolca</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pneumology 'Marius Nasta', Bucharest, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Institute of Pneumology 'Marius Nasta', Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Holcatova, Ivana" sort="Holcatova, Ivana" uniqKey="Holcatova I" first="Ivana" last="Holcatova">Ivana Holcatova</name><affiliation wicri:level="3"><nlm:affiliation>2nd Faculty of Medicine, Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>2nd Faculty of Medicine, Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Janout, Vladimir" sort="Janout, Vladimir" uniqKey="Janout V" first="Vladimir" last="Janout">Vladimir Janout</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Faculty of Medicine, University of Ostrava, Ostrava</wicri:regionArea><wicri:noRegion>Ostrava</wicri:noRegion></affiliation></author><author><name sortKey="Kontic, Milica" sort="Kontic, Milica" uniqKey="Kontic M" first="Milica" last="Kontic">Milica Kontic</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Center of Serbia, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation wicri:level="1"><nlm:affiliation>M. Sklodowska-Curie Cancer Center, Institute of Oncology, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>M. Sklodowska-Curie Cancer Center, Institute of Oncology, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Mukeria, Anush" sort="Mukeria, Anush" uniqKey="Mukeria A" first="Anush" last="Mukeria">Anush Mukeria</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre, Moscow, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Ognjanovic, Simona" sort="Ognjanovic, Simona" uniqKey="Ognjanovic S" first="Simona" last="Ognjanovic">Simona Ognjanovic</name><affiliation wicri:level="1"><nlm:affiliation>International Organization for Cancer Prevention and Research, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>International Organization for Cancer Prevention and Research, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Orlowski, Tadeusz M" sort="Orlowski, Tadeusz M" uniqKey="Orlowski T" first="Tadeusz M" last="Orlowski">Tadeusz M. Orlowski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Surgery, National Tuberculosis and Lung Diseases Research Institute, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Scelo, Ghislaine" sort="Scelo, Ghislaine" uniqKey="Scelo G" first="Ghislaine" last="Scelo">Ghislaine Scelo</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, World Health Organization, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, World Health Organization, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Swiatkowska, Beata" sort="Swiatkowska, Beata" uniqKey="Swiatkowska B" first="Beata" last="Swiatkowska">Beata Swiatkowska</name><affiliation wicri:level="1"><nlm:affiliation>Nofer Institute of Occupational Medicine, Department of Environmental Epidemiology, Lodz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Nofer Institute of Occupational Medicine, Department of Environmental Epidemiology, Lodz</wicri:regionArea><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Zaridze, David" sort="Zaridze, David" uniqKey="Zaridze D" first="David" last="Zaridze">David Zaridze</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre, Moscow, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Bakke, Per" sort="Bakke, Per" uniqKey="Bakke P" first="Per" last="Bakke">Per Bakke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Science, University of Bergen, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Science, University of Bergen, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Skaug, Vidar" sort="Skaug, Vidar" uniqKey="Skaug V" first="Vidar" last="Skaug">Vidar Skaug</name><affiliation wicri:level="3"><nlm:affiliation>National Institute of Occupational Health, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>National Institute of Occupational Health, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Zienolddiny, Shanbeh" sort="Zienolddiny, Shanbeh" uniqKey="Zienolddiny S" first="Shanbeh" last="Zienolddiny">Shanbeh Zienolddiny</name><affiliation wicri:level="3"><nlm:affiliation>National Institute of Occupational Health, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>National Institute of Occupational Health, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Butler, Lesley M" sort="Butler, Lesley M" uniqKey="Butler L" first="Lesley M" last="Butler">Lesley M. Butler</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Koh, Woon Puay" sort="Koh, Woon Puay" uniqKey="Koh W" first="Woon-Puay" last="Koh">Woon-Puay Koh</name><affiliation wicri:level="1"><nlm:affiliation>Duke-National University of Singapore Medical School, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-National University of Singapore Medical School</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S" last="Houlston">Richard S. Houlston</name><affiliation wicri:level="3"><nlm:affiliation>The Institute of Cancer Research, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mclaughlin, John" sort="Mclaughlin, John" uniqKey="Mclaughlin J" first="John" last="Mclaughlin">John Mclaughlin</name><affiliation wicri:level="1"><nlm:affiliation>Public Health Ontario, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Public Health Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L" last="Stevens">Victoria L. Stevens</name><affiliation wicri:level="2"><nlm:affiliation>American Cancer Society, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>American Cancer Society, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Joubert, Philippe" sort="Joubert, Philippe" uniqKey="Joubert P" first="Philippe" last="Joubert">Philippe Joubert</name><affiliation wicri:level="1"><nlm:affiliation>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Lamontagne, Maxime" sort="Lamontagne, Maxime" uniqKey="Lamontagne M" first="Maxime" last="Lamontagne">Maxime Lamontagne</name><affiliation wicri:level="1"><nlm:affiliation>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Nickle, David C" sort="Nickle, David C" uniqKey="Nickle D" first="David C" last="Nickle">David C. Nickle</name><affiliation wicri:level="2"><nlm:affiliation>Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Obeidat, Ma En" sort="Obeidat, Ma En" uniqKey="Obeidat M" first="Ma'En" last="Obeidat">Ma'En Obeidat</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name><affiliation wicri:level="4"><nlm:affiliation>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, GRIAC Research Institute, Groningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, GRIAC Research Institute, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Zhu, Bin" sort="Zhu, Bin" uniqKey="Zhu B" first="Bin" last="Zhu">Bin Zhu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Song, Lei" sort="Song, Lei" uniqKey="Song L" first="Lei" last="Song">Lei Song</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kachuri, Linda" sort="Kachuri, Linda" uniqKey="Kachuri L" first="Linda" last="Kachuri">Linda Kachuri</name><affiliation wicri:level="4"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Artigas, Maria Soler" sort="Artigas, Maria Soler" uniqKey="Artigas M" first="María Soler" last="Artigas">María Soler Artigas</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D" last="Tobin">Martin D. Tobin</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Wain, Louise V" sort="Wain, Louise V" uniqKey="Wain L" first="Louise V" last="Wain">Louise V. Wain</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics, Amgen, Inc., Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Amgen, Inc., Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorgeirsson, Thorgeir E" sort="Thorgeirsson, Thorgeir E" uniqKey="Thorgeirsson T" first="Thorgeir E" last="Thorgeirsson">Thorgeir E. Thorgeirsson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics, Amgen, Inc., Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Amgen, Inc., Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Reginsson, Gunnar W" sort="Reginsson, Gunnar W" uniqKey="Reginsson G" first="Gunnar W" last="Reginsson">Gunnar W. Reginsson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics, Amgen, Inc., Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Amgen, Inc., Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics, Amgen, Inc., Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Amgen, Inc., Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Hancock, Dana B" sort="Hancock, Dana B" uniqKey="Hancock D" first="Dana B" last="Hancock">Dana B. Hancock</name><affiliation wicri:level="2"><nlm:affiliation>Behavioral and Urban Health Program, Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, North Carolina, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Behavioral and Urban Health Program, Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Bierut, Laura J" sort="Bierut, Laura J" uniqKey="Bierut L" first="Laura J" last="Bierut">Laura J. Bierut</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Spitz, Margaret R" sort="Spitz, Margaret R" uniqKey="Spitz M" first="Margaret R" last="Spitz">Margaret R. Spitz</name><affiliation wicri:level="2"><nlm:affiliation>Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duncan Cancer Center, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Gaddis, Nathan C" sort="Gaddis, Nathan C" uniqKey="Gaddis N" first="Nathan C" last="Gaddis">Nathan C. Gaddis</name><affiliation wicri:level="2"><nlm:affiliation>Research Computing Division, RTI International, Research Triangle Park, North Carolina, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Research Computing Division, RTI International, Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Lutz, Sharon M" sort="Lutz, Sharon M" uniqKey="Lutz S" first="Sharon M" last="Lutz">Sharon M. Lutz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Gu, Fangyi" sort="Gu, Fangyi" uniqKey="Gu F" first="Fangyi" last="Gu">Fangyi Gu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Johnson, Eric O" sort="Johnson, Eric O" uniqKey="Johnson E" first="Eric O" last="Johnson">Eric O. Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Fellow Program and Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, North Carolina, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fellow Program and Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Kamal, Ahsan" sort="Kamal, Ahsan" uniqKey="Kamal A" first="Ahsan" last="Kamal">Ahsan Kamal</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Pikielny, Claudio" sort="Pikielny, Claudio" uniqKey="Pikielny C" first="Claudio" last="Pikielny">Claudio Pikielny</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Zhu, Dakai" sort="Zhu, Dakai" uniqKey="Zhu D" first="Dakai" last="Zhu">Dakai Zhu</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Lindstroem, Sara" sort="Lindstroem, Sara" uniqKey="Lindstroem S" first="Sara" last="Lindströem">Sara Lindströem</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Jiang, Xia" sort="Jiang, Xia" uniqKey="Jiang X" first="Xia" last="Jiang">Xia Jiang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Tyndale, Rachel F" sort="Tyndale, Rachel F" uniqKey="Tyndale R" first="Rachel F" last="Tyndale">Rachel F. Tyndale</name><affiliation wicri:level="4"><nlm:affiliation>Departments of Pharmacology and Toxicology &Psychiatry, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Pharmacology and Toxicology &Psychiatry, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><affiliation wicri:level="1"><nlm:affiliation>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Chanock, Stephen" sort="Chanock, Stephen" uniqKey="Chanock S" first="Stephen" last="Chanock">Stephen Chanock</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, World Health Organization, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, World Health Organization, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I" last="Amos">Christopher I. Amos</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="eISSN">1546-1718</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (genetics)</term><term>Adult</term><term>Aged</term><term>Chromosome Mapping</term><term>European Continental Ancestry Group (genetics)</term><term>Family Health</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Lung Neoplasms (epidemiology)</term><term>Lung Neoplasms (ethnology)</term><term>Lung Neoplasms (genetics)</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Quantitative Trait Loci</term><term>Smoking (epidemiology)</term><term>Telomere Homeostasis (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Adénocarcinome (génétique)</term><term>Cartographie chromosomique</term><term>Femelle</term><term>Génotype</term><term>Homéostasie des télomères (génétique)</term><term>Humains</term><term>Locus de caractère quantitatif</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Population d'origine européenne (génétique)</term><term>Prédisposition génétique à une maladie</term><term>Santé de la famille</term><term>Sujet âgé</term><term>Tabagisme (épidémiologie)</term><term>Tumeurs du poumon (ethnologie)</term><term>Tumeurs du poumon (génétique)</term><term>Tumeurs du poumon (épidémiologie)</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Lung Neoplasms</term><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenocarcinoma</term><term>European Continental Ancestry Group</term><term>Lung Neoplasms</term><term>Telomere Homeostasis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénocarcinome</term><term>Homéostasie des télomères</term><term>Population d'origine européenne</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Tabagisme</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Chromosome Mapping</term><term>Family Health</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Quantitative Trait Loci</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Cartographie chromosomique</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Locus de caractère quantitatif</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Santé de la famille</term><term>Sujet âgé</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Corée du Sud</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Islande</li><li>Israël</li><li>Italie</li><li>Norvège</li><li>Pays-Bas</li><li>Pologne</li><li>Roumanie</li><li>Royaume-Uni</li><li>Russie</li><li>République populaire de Chine</li><li>République tchèque</li><li>Serbie</li><li>Singapour</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Attique (région)</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>Bohême centrale</li><li>Californie</li><li>Caroline du Nord</li><li>Catalogne</li><li>Colorado</li><li>District de Karlsruhe</li><li>District fédéral central</li><li>Floride</li><li>Grand Londres</li><li>Groningue (province)</li><li>Gueldre</li><li>Géorgie (États-Unis)</li><li>Hawaï</li><li>Hovedstaden</li><li>Kentucky</li><li>Lombardie</li><li>Maryland</li><li>Massachusetts</li><li>Missouri (État)</li><li>New Hampshire</li><li>Ohio</li><li>Ontario</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Région capitale de Séoul</li><li>Tennessee</li><li>Texas</li><li>Washington (État)</li><li>Østlandet</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Cambridge</li><li>Copenhague</li><li>Groningue</li><li>Groningue (ville)</li><li>Göttingen</li><li>Heidelberg</li><li>Londres</li><li>Lyon</li><li>Milan</li><li>Moscou</li><li>Nimègue</li><li>Oslo</li><li>Prague</li><li>Saint-Louis (Missouri)</li><li>Seattle</li><li>Séoul</li><li>Toronto</li></settlement><orgName><li>Université de Cambridge</li><li>Université de Groningue</li><li>Université de Toronto</li><li>Université de Washington</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D" last="Mckay">James D. Mckay</name></region><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><name sortKey="Carreras Torres, Robert" sort="Carreras Torres, Robert" uniqKey="Carreras Torres R" first="Robert" last="Carreras-Torres">Robert Carreras-Torres</name><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><name sortKey="Scelo, Ghislaine" sort="Scelo, Ghislaine" uniqKey="Scelo G" first="Ghislaine" last="Scelo">Ghislaine Scelo</name><name sortKey="Timofeeva, Maria N" sort="Timofeeva, Maria N" uniqKey="Timofeeva M" first="Maria N" last="Timofeeva">Maria N. Timofeeva</name></country><country name="Canada"><region name="Ontario"><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J" last="Hung">Rayjean J. Hung</name></region><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><name sortKey="Brhane, Yonathan" sort="Brhane, Yonathan" uniqKey="Brhane Y" first="Yonathan" last="Brhane">Yonathan Brhane</name><name sortKey="Joubert, Philippe" sort="Joubert, Philippe" uniqKey="Joubert P" first="Philippe" last="Joubert">Philippe Joubert</name><name sortKey="Kachuri, Linda" sort="Kachuri, Linda" uniqKey="Kachuri L" first="Linda" last="Kachuri">Linda Kachuri</name><name sortKey="Lam, Stephen" sort="Lam, Stephen" uniqKey="Lam S" first="Stephen" last="Lam">Stephen Lam</name><name sortKey="Lamontagne, Maxime" sort="Lamontagne, Maxime" uniqKey="Lamontagne M" first="Maxime" last="Lamontagne">Maxime Lamontagne</name><name sortKey="Leighl, Natasha" sort="Leighl, Natasha" uniqKey="Leighl N" first="Natasha" last="Leighl">Natasha Leighl</name><name sortKey="Liu, Geoffrey" sort="Liu, Geoffrey" uniqKey="Liu G" first="Geoffrey" last="Liu">Geoffrey Liu</name><name sortKey="Mclaughlin, John" sort="Mclaughlin, John" uniqKey="Mclaughlin J" first="John" last="Mclaughlin">John Mclaughlin</name><name sortKey="Obeidat, Ma En" sort="Obeidat, Ma En" uniqKey="Obeidat M" first="Ma'En" last="Obeidat">Ma'En Obeidat</name><name sortKey="Shepherd, Frances A" sort="Shepherd, Frances A" uniqKey="Shepherd F" first="Frances A" last="Shepherd">Frances A. Shepherd</name><name sortKey="Tsao, Ming Sound" sort="Tsao, Ming Sound" uniqKey="Tsao M" first="Ming-Sound" last="Tsao">Ming-Sound Tsao</name><name sortKey="Tyndale, Rachel F" sort="Tyndale, Rachel F" uniqKey="Tyndale R" first="Rachel F" last="Tyndale">Rachel F. Tyndale</name><name sortKey="Zong, Xuchen" sort="Zong, Xuchen" uniqKey="Zong X" first="Xuchen" last="Zong">Xuchen Zong</name></country><country name="États-Unis"><region name="New Hampshire"><name sortKey="Han, Younghun" sort="Han, Younghun" uniqKey="Han Y" first="Younghun" last="Han">Younghun Han</name></region><name sortKey="Albanes, Demetrios" sort="Albanes, Demetrios" uniqKey="Albanes D" first="Demetrios" last="Albanes">Demetrios Albanes</name><name sortKey="Aldrich, Melinda C" sort="Aldrich, Melinda C" uniqKey="Aldrich M" first="Melinda C" last="Aldrich">Melinda C. Aldrich</name><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I" last="Amos">Christopher I. Amos</name><name sortKey="Andrew, Angeline S" sort="Andrew, Angeline S" uniqKey="Andrew A" first="Angeline S" last="Andrew">Angeline S. Andrew</name><name sortKey="Arnold, Susanne M" sort="Arnold, Susanne M" uniqKey="Arnold S" first="Susanne M" last="Arnold">Susanne M. Arnold</name><name sortKey="Barnett, Matt P" sort="Barnett, Matt P" uniqKey="Barnett M" first="Matt P" last="Barnett">Matt P. Barnett</name><name sortKey="Bierut, Laura J" sort="Bierut, Laura J" uniqKey="Bierut L" first="Laura J" last="Bierut">Laura J. Bierut</name><name sortKey="Bush, William S" sort="Bush, William S" uniqKey="Bush W" first="William S" last="Bush">William S. Bush</name><name sortKey="Butler, Lesley M" sort="Butler, Lesley M" uniqKey="Butler L" first="Lesley M" last="Butler">Lesley M. Butler</name><name sortKey="Byun, Jinyoung" sort="Byun, Jinyoung" uniqKey="Byun J" first="Jinyoung" last="Byun">Jinyoung Byun</name><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><name sortKey="Chanock, Stephen" sort="Chanock, Stephen" uniqKey="Chanock S" first="Stephen" last="Chanock">Stephen Chanock</name><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C" last="Christiani">David C. Christiani</name><name sortKey="Diao, Nancy" sort="Diao, Nancy" uniqKey="Diao N" first="Nancy" last="Diao">Nancy Diao</name><name sortKey="Doherty, Jennifer A" sort="Doherty, Jennifer A" uniqKey="Doherty J" first="Jennifer A" last="Doherty">Jennifer A. Doherty</name><name sortKey="Gaddis, Nathan C" sort="Gaddis, Nathan C" uniqKey="Gaddis N" first="Nathan C" last="Gaddis">Nathan C. Gaddis</name><name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E" last="Goodman">Gary E. Goodman</name><name sortKey="Gu, Fangyi" sort="Gu, Fangyi" uniqKey="Gu F" first="Fangyi" last="Gu">Fangyi Gu</name><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><name sortKey="Hancock, Dana B" sort="Hancock, Dana B" uniqKey="Hancock D" first="Dana B" last="Hancock">Dana B. Hancock</name><name sortKey="Haura, Eric B" sort="Haura, Eric B" uniqKey="Haura E" first="Eric B" last="Haura">Eric B. Haura</name><name sortKey="Ji, Xuemei" sort="Ji, Xuemei" uniqKey="Ji X" first="Xuemei" last="Ji">Xuemei Ji</name><name sortKey="Jiang, Xia" sort="Jiang, Xia" uniqKey="Jiang X" first="Xia" last="Jiang">Xia Jiang</name><name sortKey="Johnson, Eric O" sort="Johnson, Eric O" uniqKey="Johnson E" first="Eric O" last="Johnson">Eric O. Johnson</name><name sortKey="Kamal, Ahsan" sort="Kamal, Ahsan" uniqKey="Kamal A" first="Ahsan" last="Kamal">Ahsan Kamal</name><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><name sortKey="Lazarus, Philip" sort="Lazarus, Philip" uniqKey="Lazarus P" first="Philip" last="Lazarus">Philip Lazarus</name><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><name sortKey="Li, Yafang" sort="Li, Yafang" uniqKey="Li Y" first="Yafang" last="Li">Yafang Li</name><name sortKey="Lindstroem, Sara" sort="Lindstroem, Sara" uniqKey="Lindstroem S" first="Sara" last="Lindströem">Sara Lindströem</name><name sortKey="Lutz, Sharon M" sort="Lutz, Sharon M" uniqKey="Lutz S" first="Sharon M" last="Lutz">Sharon M. Lutz</name><name sortKey="Nickle, David C" sort="Nickle, David C" uniqKey="Nickle D" first="David C" last="Nickle">David C. Nickle</name><name sortKey="Pikielny, Claudio" sort="Pikielny, Claudio" uniqKey="Pikielny C" first="Claudio" last="Pikielny">Claudio Pikielny</name><name sortKey="Qian, David C" sort="Qian, David C" uniqKey="Qian D" first="David C" last="Qian">David C. Qian</name><name sortKey="Schabath, Matthew B" sort="Schabath, Matthew B" uniqKey="Schabath M" first="Matthew B" last="Schabath">Matthew B. Schabath</name><name sortKey="Song, Lei" sort="Song, Lei" uniqKey="Song L" first="Lei" last="Song">Lei Song</name><name sortKey="Spitz, Margaret R" sort="Spitz, Margaret R" uniqKey="Spitz M" first="Margaret R" last="Spitz">Margaret R. Spitz</name><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L" last="Stevens">Victoria L. Stevens</name><name sortKey="Su, Li" sort="Su, Li" uniqKey="Su L" first="Li" last="Su">Li Su</name><name sortKey="Wilkens, Lynne R" sort="Wilkens, Lynne R" uniqKey="Wilkens L" first="Lynne R" last="Wilkens">Lynne R. Wilkens</name><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name><name sortKey="Xiao, Xiangjun" sort="Xiao, Xiangjun" uniqKey="Xiao X" first="Xiangjun" last="Xiao">Xiangjun Xiao</name><name sortKey="Ye, Yuanqing" sort="Ye, Yuanqing" uniqKey="Ye Y" first="Yuanqing" last="Ye">Yuanqing Ye</name><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name><name sortKey="Zhang, Ruyang" sort="Zhang, Ruyang" uniqKey="Zhang R" first="Ruyang" last="Zhang">Ruyang Zhang</name><name sortKey="Zhu, Bin" sort="Zhu, Bin" uniqKey="Zhu B" first="Bin" last="Zhu">Bin Zhu</name><name sortKey="Zhu, Dakai" sort="Zhu, Dakai" uniqKey="Zhu D" first="Dakai" last="Zhu">Dakai Zhu</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Dunning, Alison" sort="Dunning, Alison" uniqKey="Dunning A" first="Alison" last="Dunning">Alison Dunning</name></region><name sortKey="Artigas, Maria Soler" sort="Artigas, Maria Soler" uniqKey="Artigas M" first="María Soler" last="Artigas">María Soler Artigas</name><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><name sortKey="Davies, Michael P A" sort="Davies, Michael P A" uniqKey="Davies M" first="Michael P A" last="Davies">Michael P A. Davies</name><name sortKey="Field, John K" sort="Field, John K" uniqKey="Field J" first="John K" last="Field">John K. Field</name><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S" last="Houlston">Richard S. Houlston</name><name sortKey="Marcus, Michael W" sort="Marcus, Michael W" uniqKey="Marcus M" first="Michael W" last="Marcus">Michael W. Marcus</name><name sortKey="Muller, David C" sort="Muller, David C" uniqKey="Muller D" first="David C" last="Muller">David C. Muller</name><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A" last="Pooley">Karen A. 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Reginsson</name><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><name sortKey="Thorgeirsson, Thorgeir E" sort="Thorgeirsson, Thorgeir E" uniqKey="Thorgeirsson T" first="Thorgeir E" last="Thorgeirsson">Thorgeir E. Thorgeirsson</name></country><country name="Australie"><noRegion><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name></noRegion><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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